Switchable Lipid Provides pH-Sensitive Properties to Lipid and Hybrid Polymer/Lipid Membranes

Lipid Properties in Membranes

branes separating two aqeous phases: Formation of a membrane of a single composition," J. Mol. Biol. 8 (1964): 148-160. 38. Ghosh, D., M. A. Williams, and J. Tinoco, "The influence of lecithin structure on their monolayer behavior and interactions with cholesterol," Biochim, Biophys. Acta 291 (1973): 351-362. 39. MacDonald, R. C., and S. A. Simon, "Lipid monolayer states and their relationships...

Lipid Membranes

pH-dependent effects of local anaesthetics in perturbing lipid membranes.

The effects of local anaesthetics lidocaine, benzocaine, carbisocaine and carbisocaine derivatives, KaQ-7 and Ka-O, in perturbing bovine brain lipid membranes or egg lecithin membranes were compared at pH 6.0; 7.0; and 8.0. The electron spin resonance method with stearic acid labeled at carbon position 16 as the spin probe was employed. The perturbation effects of lidocaine and Ka-O were found ...

Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems.

Curcumin is a perspective drug candidate with pleiotropic antineoplastic activity, whose exceptionally low aqueous solubility and poor pharmacokinetic properties have hampered its development beyond the preclinical level. A possible approach to overcome these limitations is the encapsulation of curcumin into nano-carriers, incl. liposomes. The present contribution is focused on feasibility of u...

Permeability and Electrical Properties of Thin Lipid Membranes

We present and discuss the permeability and electrical properties of thin lipid membranes, and the changes induced in these properties by several agents added to the aqueous phases after the membranes have formed. The unmodified membrane is virtually impermeable to ions and small "hydrophilic" solutes, but relatively permeable to water and "lipophilic" molecules. These properties are consistent...